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REPRISE DE CERTAINS SÉMINAIRES EN AMPHI SUR LE CAMPUS, INDIQUÉS "PRÉSENTIEL".

POUR LES SÉMINAIRES EN VISIOCONFERENCE, SI VOUS SOUHAITEZ ASSISTER A L'UN DEUX, MERCI DE CONTACTER BRIGITTE JARRIN QUI VOUS ENVERRA LE LIEN. secretariat@crc.jussieu.fr

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  Monday, July 5, 16h00

                    CYCLE ETHIQUE DU CRC                  

 Les rendez-vous Ethique du CRC

Voyage au laboratoire 2.0 :

le cahier de laboratoire électronique

Laetitia LE POTTIER

(GTIS INSERM)

Invitée par Laura Sénovilla, (Equipe G. Kroemer) 

Résumé : Le cahier de laboratoire électronique (CLE) est un excellent outil pour pallier aux nombreux écueils rencontrés avec le cahier papier. Il permet une meilleure traçabilité des échantillons, des expériences et des données associées. La paternité des expériences est automatiquement tracée permettant d’éviter certains problèmes d’intégrité scientifique. En plus, d’être un cahier de laboratoire, le CLE offre de nombreuses options : la gestion des consommables, des équipements, le stockage d’échantillons …

Le CLE peut être utilisé de diverses manières et s’adapter à votre façon de travailler, selon vos besoins, la taille de votre équipe et l’organisation de vos projets : c’est à vous de faire le choix, et nous verrons ensemble comment optimiser son installation et son utilisation.

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 Thursday, July 8, 13h30

SEMINAIRE TECHNIQUE

High resolution characterization of tissue
complexity and tumor microenvironment with
single single cell and spatial multiomics

 

Christophe FLEURY

(10X Génomics)

et

Retour d'expérience de l'équipe Cremer

Invités par Chiara Maiuri

Summary : The vast complexities of biology require approaches to build a complete picture, starting from single cells to tissues and beyond. Single cell and spatial solutions enable researchers to drive the leading edge of what’s possible. Resolve highly complex biological systems, while bringing into focus the details that matter most.
Join us for this webinar to learn how Chromium Single Cell Solutions and Visium Spatial Solutions from 10x Genomics can help you push the boundaries of your research. Uncover molecular insights, dissect cell-type differences, tissue heterogeneity, investigate the adaptive immune system, detect novel subtypes and biomarkers, and map the epigenetic landscape cell by cell. Enabling deeper insight into cancer, immunology or neuroscience gives researchers the ability to see biology at true resolution.

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 Monday, September 6, 13h30

CYCLE ETHIQUE DU CRC

 Les rendez-vous Ethique du CRC

Comment utiliser des animaux

dans un projet scientifique

en respectant le cadre réglementaire

 

Jérôme YELNIK

(Président du Comité d'Ethique

en expérimentation animale Darwin)

Invité par Marie-France Mamzer et Chiara Maiuri

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Thursday, September 9, 13h30

SEMINAIRE EXTERIEUR

Mitochondrial form and function

in health and disease

 

Timothy WAI

(Institut Pasteur, Paris)

Invité par Fabienne Foufelle, Marie Lagouge  et Jessica Zucman-Rossi

Summary : Mitochondria are essential organelles whose morphology varies tremendously across cell types and tissues. Balanced fusion and fission events shape mitochondria to meet metabolic demands and to ensure removal of damaged organelles. The dynamism of mitochondria is highlighted by the dramatic changes in morphology they undergo in response to metabolic inputs. The morphology of mitochondria is inextricably linked to its many essential functions in the cell and we are interested in understanding the relationship between mitochondrial shape changes and metabolism in the context of acquired and inborn human diseases. We recently established a high-throughput imaging pipeline using supervised machine learning (ML) to perform unbiased, quantitative mitochondrial morphology analysis that was coupled with a bespoke siRNA library targeting the entire known mitochondrial proteome (1531 genes), providing a detailed phenotypic screening of human fibroblasts. In my talk, I will discuss the insights we have made regarding the regulation of mitochondrial morphology and its importance for cellular homeostasis.

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 Thursday, September 16, 13h30

SEMINAIRE EXTERIEUR

Titre en attente

 

Florent GINHOUX

(Institut Gustave Roussy)

Invité par Nicolas Venteclef et Jessica Zucman-Rossi

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Thursday, September 30, 13h30

SEMINAIRE EXTERIEUR

The peptidoglycan as a signaling molecule in

host-microbe interactions

 

Ivo GOMPERTS BONECA

(Institut Pasteur)

Invité par Michel Arthur et Jessica Zucman-Rossi

Summary : His research can be separated in two complementary subjects: 1) the study of peptidoglycan (PG) metabolism and its role in cell physiology and antibiotic resistance, and 2) the role that cell wall, and in particular, PG metabolism has on host-microbe interactions. In particular on this last aspect, he is interested in studying the effects of PG as a signaling molecule on host physiology. The PG is constantly released by the gut commensal flora and transported systemically in the host. Some of the effects are local on the gut homeostasis but others occur at distant tissues and organs. The brain is such an organ where the PG can be found exclusively after oral but not after systemic administration. We show that the process is dependent on a mature microbiota, on the parasympathetic system and partially mediated by exosomes.
1. Dias Bastos PA, R Wheeler, IG Boneca. 2021. Uptake, recognition and responses to peptidoglycan in the mammalian host. FEMS Microbiol Rev. 45(1):fuaa044.
2. Macho Fernandez E, V Valenti, C Rockel, C Hermann, B Pot, IG Boneca,C Grangette. 2011. Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide. Gut. 60(8):1050-1059.
3. Bouskra D, C Brézillon, M Bérard, C Werts, R Varona, IG Boneca, G Eberl. 2008. Lymphoid tissue genesis induced by bacterial commensals through NOD1 and β-defensin regulates intestinal homeostasis. Nature. 456(7221):507-510.

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Thursday, October 14, 13h30

SEMINAIRE EXTERIEUR

Titre en attente

 

Rodrigue ROSSIGNOL

(MRGM Bordeaux)

Invité par Fatima Djouadi et Jessica Zucman-Rossi

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Thursday, November 4, 13h30

SEMINAIRE EXTERIEUR

Titre en attente

 

Céline VALLOT

(Institut Curie)

Invitée par Angélique Gougelot et Jessica Zucman-Rossi

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 Thursday, November 25, 13h30

SEMINAIRE EXTERIEUR

Titre en attente

 

Claudia KEMPER

(NIH Bethesda, USA)

Invitée par Lubka Roumenina et Jessica Zucman-Rossi

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