AccueilAccueil>Research>Teams>Guido KROEMER

Apoptosis, cancer, immunity

Our team is best known for the discovery that, in programmed cell death (apoptosis), mitochondrial membrane permeabilization constitutes the point-of-no-return of the lethal process and thus defines the apoptotic checkpoint. Later, we provided an operational definition of "mitotic catastrophe" as an oncosuppressive mechanism, launched the debate that necrosis may be a regulated cell death event, and showed that autophagy usually is a cytoprotective event that avoids cell death and actually prolongs longevity when it is induced at the whole-organism level. We deciphered part of the molecular crosstalk between apoptosis and autophagy. We identified spermidine as a novel, non-toxic inducer of autophagy and determined its mode of action as a life span-extending drug. We launched the (still valid) hypothesis that all longevity extending manipulations, be they pharmacological or genetic, must induce autophagy to be efficient. Recently, we invalidated the dogma that apoptosis is a non-immunogenic cell death modality. We demonstrated that, depending on the upstream triggers, apoptosis can be immunogenic and hence alert the innate immune system and instruct it to stimulate a cognate response against dead-cell antigens. This has opened a new field of research at the frontier between immunology and cell biology, allowing us to define the molecular properties of immunogenic cell death. Our current research projects are designed to discover the pathophysiological implications of cell death, mostly in the context of cancer and immunosurveillance.



Team Leader:  Guido KROEMER (Pr) 

Team Members:  Maria CASTEDO (Dr),  Olivier KEPP (Dr), Maria Chiara MAIURI (Dr), Laura SENOVILLA (Dr), Thierry SOUSSI (Dr), Sabrina SPAGGIARI (Dr), Naoufal ZAMZAMI (Dr).

Sylvère DURAND (Eng), Lorella GHONEIMI (Tec), Sylvie LACHKAR (Eng), Isabelle MARTINS (Eng), Allan SAUVAT (Eng), Valentina SICA (Eng), Gautier STOLL (Eng), Erika VACHELLI (Eng).

Elisa Elena BARACCO (PhD), Lucilla BEZU (PhD), Francesca CASTOLDI (PhD), Giulia CERRATO (PhD), Guo CHEN (Post-Doc), Fatima DE PALMA (PhD), Juliette HUMEAU (PhD), Valentina IZZO (Post-Doc), Sarah LEVESQUE (PhD),  Peng LIU (PhD), Friedemann LOOS (Post-Doc), Florine OBRIST (PhD), Juliette PAILLET (PhD), Juncheng PAN (PhD), Maria PEREZ LANZON (PhD), Adriana PETRAZUOLO (PhD), Jonathan POL (Post-Doc), José Manuel SAN PEDRO (Post-Doc), Ligia SILVA (Post-Doc), Yan WANG (Post Doc), Wei XIE (Doc), Shaoyi ZHANG (PhD), Liwei ZHAO (Post-Doc).

Administration: Lynda BENNACI

Contact details: 33 1 44 27 76 67  Email:

Selected publications

  • Michaud M, Martin I, Sukkuwala A, Adjemian S, Ma Y, Pellegati P, Shen S, Kepp O, Scoazec M, Mignot G, Rello-Varona S, Tailler M, Menger L, Vacchelli E, Galluzzi L, Ghiringhelli F, Galluzzi L, di Virgilio F, Zitvogel L, Kroemer G. Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science. 2011 Dec16;334:1573-1577
  • Senovilla L, Vitale I, Martins I, Tailler M, Pailleret C, Michaud M, Galluzzi  L, Adjemian S, Kepp O, López-Otín C, Smyth MJ, Zitvogel L, Castedo M, Kroemer G. An immunosurveillance mechanism controls cancer cell ploidy. Science. 2012 Sep 28;337(6102):1678-84.
  • Ma Y, Adjemian S, Mattarollo SR, Yamazaki T, Aymeric L, Yang H, Portela Catani JP, Hannani D, Duret H, … Van Endert P, Solary E, Smyth MJ, Zitvogel L, Kroemer G. Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity. 2013 Apr 18;38(4):729-41
  • López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013 Jun 6;153(6):1194-217.
  • Sistigu A, Yamazaki T, Vacchelli E, Chaba K, Enot DP, Adam J, Vitale I, Goubar A, Baracco EE, Remédios C, Fend L, Hannani D, Aymeric L, Ma Y, Niso-Santano M, Kepp O, Schultze JL, Tüting T, Belardelli F, Bracci L, La Sorsa V, Urbani F, Delorenzi M, Lacroix-Triki M, Quidville V, Conforti R, Spano JP, Pusztai L, Poirier-Colame V, Delaloge S, Penault-Llorca F, Ladoire S, Arnould L, Cyrta J, Dessoliers MC, Eggermont A, Bianchi ME, Pittet M, Engblom C, Pfirschke C, Préville X, Uzè G, Schreiber RD, Chow MT, Smyth MJ, Proietti E, André F, Kroemer G*, Zitvogel L. (*Corresponding author and co-senior author). Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Nat Med. 2014 Nov;20(11):1301-1309.
  • Lissa D, Senovilla L, Rello-Varona S, Vitale I, Michaud M, Pietrocola F, Boilève A, Bordenave C, Garcia P, Michels J, Jeema M, Galluzzi L, Kepp O, Castedo M, Kroemer G. Resveratrol and salicylate eliminate tetraploid cells for anticancer chemoprevention. Proc Natl Acad Sci USA 2014 Feb 25;111(8):3020-5.
  • Green DR, Galluzzi L, Kroemer G. Cell biology. Metabolic control of cell death. Science. 2014 Sep 19;345(6203):1250256.
  • Galluzzi L, Pietrocola F, Levine B, Kroemer G. Metabolic control of autophagy. Cell. 2014 Dec 4;159(6):1263-1276.
  • Mariño G, Pietrocola F, Eisenberg T, Kong Y, Malik SA, Andryushkova A, Schroeder S, Pendl T, Harger A, Niso-Santano M, Zamzami N, Scoazec M, Durand S, Enot DP, Fernández ÁF, Martins I, Kepp O, Senovilla L, Bauvy C, Morselli E, Vacchelli E, Bennetzen M, Magnes C, Sinner F, Pieber T, López-Otín C, Maiuri MC,  Codogno P, Andersen JS, Hill JA, Madeo F, Kroemer G. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53(5):710-25.
  • Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam NV, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini JL, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P,  Piacentini M, Ruvo M, Blomgren K, Kroemer G*, Modjtahedi N. (*corresponding and co-senior author). Interaction between AIF and CHCHD4 regulates respiratory chain biogenesis. Mol Cell. 2015 Jun 18;58(6):1001-14.

    Link to PubMed

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