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Department 2

The teams of the Cancer Immunology and Immunopathology Department conduct collaborative research to study the crosstalk between cancer and the immune system, in particular in the tumor microenvironment and how therapies that induce stress signals (chemotherapy, antibody therapy) can be used to stimulate the immune response against tumors. Strategies aimed at inducing cancer cell death and to overcome chemo-resistance are developed in parallel.
A second project investigates the physio-pathological aspects of autoimmune and inflammation-related pathologies diseases, including hemophilia and as well as genetic and acquired deficiencies abnormalities in the components of the complement componentssystem. The mechanisms of action of therapeutic polyclonal intravenous immunoglobulins and the role of local inflammatory responses on their effects are studied in parallel.
All teams conduct basic and translational research in order to identify new cancer  prognosis markers  and predictive biomarkers, and to ameliorate current therapies. Our research is conducted in Humans and also uses  experimental models. It combines large-scale studies in cell biology, immunohistochemistry, and transcriptomics and intermolecular interactions, using state-of-the-art technologies coupled to extensive analyses in bioinformatics and biostatistics.

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