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Séminaires du CRC



 

  • Vendredi 8 Mars, 11h30, Amphitéâtre Gustave ROUSSY

    Angela VASATURO
    (Ultivue EMEA)

    Make the tumor microencironment complexity easy and fast to unravel : End-to-End Application of UltiMappe TM Kits for Multiplexed Immuno-Profiling
    Compare tissue multiplex technologies and learn how UltiMapper multiplex IHC assays enable access to whole-slide, highly multiplexed biomarker data optimized on the Leica BOND RX™ autostainer and analyzed using HALO™ image analysis softwar

    Invitée par Isabelle CREMER

  • Vendredi 15 Mars, 11h30, Faculté de Médecine Bâtiment de la surélévation salle 210 - 2° étage 

    SEMINAIRES JEUNES CHERCHEURS :

    Robin Loesch
    Team: Oncogenic functions of beta-catenin signaling in the liver

    Mouse models for β-catenin-dependent liver carcinogenesis
    The hepatocellular carcinoma (HCC) is the most common form of primitive liver cancer and the second cause of cancer related death worldwide. About 30% of HCCs are characterized by activation of the Wnt/β-catenin pathway, mostly due to activating mutations of CTNNB1, the gene encoding the B-catenin. This research project aims to demonstrate the oncogenic potential of Ctnnb1 exon 3 deletion using CRISPR/Cas9 in vivo. This allows the deletion of Ctnnb1 exon 3 by targeting simultaneously intron 2 and 3. Even if the exon 3 deletion is well described in human HCCs its oncogenic properties has not been demonstrated in mice. This is why this model will be compared to 1- a murine model of liver carcinogenesis induced by hepatic-specific Cre-loxP mediated disruption of Apc inducing B-catenin activation in the liver 2- a Cre-loxP model of Ctnnb1 Exon 3 deletion.

    Emilie Picard
    Team: Physiopathology of ocular diseases: therapeutic innnovations

    Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection
    In retinal detachment (RD), photoreceptor death and permanent vision loss is caused by neurosensory retina separating from the retinal pigment epithelium because of subretinal fluid (SRF), and successful surgical reattachment is not predictive of total visual recovery. As retinal iron overload exacerbates cell death in retinal diseases, we assessed iron as a predictive marker and therapeutic target for RD. In the vitreous and SRF from RD patients, we measured increased iron and transferrin (TF) saturation that is correlated with poor visual recovery. In ex vivo and in vivo RD models, iron induces immediate necrosis and delayed apoptosis. We demonstrate that TF decreases both apoptosis and necroptosis induced by RD and using RNA sequencing, pathways mediating the neuroprotective effects of TF are identified. Since toxic iron accumulates in RD, we propose TF supplementation as an adjunctive therapy to surgery for improving the visual outcomes of RD patients.


  • Vendredi 22 Mars, 11h30, Amphithéâtre Gustave ROUSSY

    Mejda BEN SLAMA (DRH - INSERM)
    Améliorer le Bien-être au travail : Tous Acteurs !
    Le bien-être au travail est un enjeu de plus en plus important à l’Inserm; pour des questions de santé mais aussi des questions de qualité du travail.
    Cette présentation est composée de deux parties : comment l'organisation du travail agit sur la qualité du travail, le bien-être et l'investissement au travail. La deuxième partie portera sur les comportements nocifs au travail.
    Cette présentation a pour but de saisir les interactions entre organisation du travail, comportements au travail et qualité de vie au travail.

    Invitée par Chiara MAIURI et Edith DOUCET

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