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DU FAIT DE LA SITUATION SANITAIRE, TOUS NOS SEMINAIRES SONT ACTUELLEMENT EN VISIOCONFERENCE. SI VOUS SOUHAITEZ ASSISTER A L'UN DEUX, MERCI DE CONTACTER BRIGITTE JARRIN QUI VOUS ENVERRA LE LIEN. secretariat@crc.jussieu.fr

   
        
Thursday, May 20, 13h30

SÉMINAIRE EXTERIEUR

                                         

 Overcoming immune mediated barriers to

successful in vivo gene transfer

Federico MINGOZZI 

(Sparks Therapeutics, USA)

Invité par Jessica Zucman-Rossi et Sébastien Lacroix-Desmazes

Adeno-associated viral (AAV) vector gene therapy has shown promise as a possible curative treatment for a number of inherited diseases. However, immune responses directed against AAV vectors remain a hurdle to the broader use of this gene transfer platform. 
Innate and adaptive immune responses directed against the AAV vector capsid or their components can affect the safety and efficacy of gene transfer in humans, in some cases resulting in significant toxicities.  
This presentation will focus on what is known about pre-existing immunity to AAV in humans, what we learned about vector immunogenicity from preclinical studies and clinical trials and on potential strategies to modulate immune responses in gene transfer. 

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 Thursday, May 27, 13h30

JEUNE CHERCHEUR

                                          Stratégies thérapeutiques compensatoires

en cas de perte de fonction du récepteur

de peptide formyle 1

Julie LE NAOUR

(Equipe Guido KROEMER)

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 Thursday, June 3, 13h30

JEUNE CHERCHEUR

                                          Titre en attente

Margot REVEL

(Equipe Isabelle CREMER) 
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Thursday, June 10, 13h30

SEMINAIRE EXTERIEUR

Role of stromal heterogeneity in metastatic spread,

immunosuppresion and resistance

to immunotherapy in breast cancer

Fatima Mechta-Grigoriou

(Institut Curie)

Invitée par Jessica Zucman-Rossi

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Thursday, June 17, 13h30

SEMINAIRE EXTERIEUR

A monocyte/dendritic cell molecular signature of

SARS-CoV-2 related multisystem inflammatory

syndrome in children (MIS-C)

with severe myocarditis.

Mickaël Ménager

(Institut Imagine)

Invité par Claire Vandiedonck, Equipe 17

 

SARS-CoV-2 infection in children is generally milder than in adults, yet a proportion of cases result in hyperinflammatory conditions often including myocarditis. To better understand these cases, we applied a multi-parametric approach to the study of blood cells of 56 children hospitalized with suspicion of SARS-CoV-2 infection. The most severe forms of MIS-C (multisystem inflammatory syndrome in children related to SARS-CoV-2), that resulted in myocarditis, were characterized by elevated levels of pro-angiogenesis cytokines and several chemokines. Single-cell transcriptomic analyses identified a unique monocyte/dendritic cell gene signature that correlated with the occurrence of severe myocarditis, characterized by sustained NF-kB activity, TNF alpha signaling, associated with decreased gene expression of NF-kB inhibitors. We also found a weak responsa to type-I and type-II interférons, hyperinflammation and response to oxidative strress related to increased HIF1alpha and VEGF signaling. These results provide potential for a better understanding of disease pathophysiology.

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 Thursday, June 24, 13h30

JEUNE CHERCHEUR

                                         

 Epigenomic regulation of IL1B Enhancers

in Type 2 diabetes

Elena CARCARINO 

(Equipe Nicolas VENTECLEF) 
       

IL-1β has a well-established role in the pathogenesis of type 2 diabetes (T2D) and its related cardiovascular complications. Despite the promising anti-diabetic effect of blocking IL-1β action, little is known about the regulation of IL-1β gene (IL1B) expression in diabetic participants. Recent evidences from human monocytes of healthy donors demonstrated that, in response to inflammatory stimuli, IL1B transcription is influenced by genomic regions called “enhancers”, containing binding sites of Transcription Factors (TF) . In our current human study, we aim to decode and functionally characterize the enhancer dynamics and TFs regulating IL1B gene transcription in T2D monocytes participants.

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  Monday, July 5, 16h00

CYCLE ETHIQUE DU CRC

                                         

 Les rendez-vous Ethique du CRC

Titre en attente

Laetitia Le Pottier

(GTIS Inserm)

Invitée par Laura Sénovilla, (Equipe G. Kroemer)

 

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  Monday, September 6, 13h30

CYCLE ETHIQUE DU CRC

                                         

 Les rendez-vous Ethique du CRC

Titre en attente

Jérôme YELNIK

(Président du Comité d'Ethique

en expérimentation animaleDarwin)

Invitée par Marie-France Mamzer et Chiara Maiuri

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Thursday, September 16, 13h30

SEMINAIRE EXTERIEUR

Titre en attente

Florent GINHOUX

(Institut Gustave Roussy)

Invité par Nicolas Venteclef et Jessica Zucman-Rossi

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Thursday, September 30, 13h30

SEMINAIRE EXTERIEUR

The peptidoglycan as a signaling molecule in

host-microbe interactions

Ivo Gomperts Boneca

(Institut Pasteur)

Invité par Michel Arthur et Jessica Zucman-Rossi

His research can be separated in two complementary subjects: 1) the study of peptidoglycan (PG) metabolism and its role in cell physiology and antibiotic resistance, and 2) the role that cell wall, and in particular, PG metabolism has on host-microbe interactions. In particular on this last aspect, he is interested in studying the effects of PG as a signaling molecule on host physiology. The PG is constantly released by the gut commensal flora and transported systemically in the host. Some of the effects are local on the gut homeostasis but others occur at distant tissues and organs. The brain is such an organ where the PG can be found exclusively after oral but not after systemic administration. We show that the process is dependent on a mature microbiota, on the parasympathetic system and partially mediated by exosomes.
1. Dias Bastos PA, R Wheeler, IG Boneca. 2021. Uptake, recognition and responses to peptidoglycan in the mammalian host. FEMS Microbiol Rev. 45(1):fuaa044.
2. Macho Fernandez E, V Valenti, C Rockel, C Hermann, B Pot, IG Boneca,C Grangette. 2011. Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide. Gut. 60(8):1050-1059.
3. Bouskra D, C Brézillon, M Bérard, C Werts, R Varona, IG Boneca, G Eberl. 2008. Lymphoid tissue genesis induced by bacterial commensals through NOD1 and β-defensin regulates intestinal homeostasis. Nature. 456(7221):507-510.

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Thursday, October 14, 13h30

SEMINAIRE EXTERIEUR

Titre en attente

Rodrigue Rossignol

(MRGM Bordeaux)

Invité par Fatima Djouadi et Jessica Zucman-Rossi

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Thursday, November 25, 13h30

SEMINAIRE EXTERIEUR

Titre en attente

Claudia Kemper

(NIH Bethesda, Israël)

Invité par Lubka Roumenina et Jessica Zucman-Rossi

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