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Metabolism, Cancer & Immunity

Our team "Metabolism, Cancer & Immunity" is interested in the comprehension of intracellular and extracellular stress pathways following an “inside-outside” communication that must be deciphered in its molecular details. Organellar stress pathways (that operate inside cells) give rise to cellular manifestations (apoptosis, autophagy, ferroptosis, necroptosis, senescence etc.) that in fine cause alterations in the extracellular milieu (outside cells) via the active or passive release of metabolites and macromolecules that act on receptors on neighboring cells and cause homeostatic or pathogenic reactions via inflammatory/immune or neuroendocrine pathways. By deciphering the rules that determine the “inside-outside” communication of stress, we attempt to understand the pathophysiology of aging and aging-related morbidities, placing special emphasis on cancer and its treatment with chemotherapy or immunotherapy. We attempt to achieve these goals by using metabolomics and cell biological high-throughput technology within a continuum between fundamental, pharmacological translational and clinical research. In synthesis, our main interest is the comprehension of pathways that link cellular stress to organellar and organismal pathophysiology, laying special emphasis on the anticancer immune response, including its control by the intestinal microbiota. We are also interested in major metabolic perturbations (such as obesity & metabolic syndrome) that cause human disease, as well as in the pathophysiology of the two most frequent lethal monogenetic human diseaes, which are cystic fibrosis and Wilson disease.

 

Team Leader : Guido KROEMER (PU-PH; Univ Paris Descartes)

 

Team Members:

Researchers: Maria CASTEDO (CR; Inserm),  Olivier KEPP (CR; Inserm), Maria Chiara MAIURI (CR; Inserm), Laura SENOVILLA (CR; Inserm), Thierry SOUSSI (PU, Sorbonne Univ), Sabrina SPAGGIARI (Chargée Etudes; Gustave Roussy), Naoufal ZAMZAMI (CR; Inserm).

Technical Staff: Sylvère DURAND (IR; Gustave Roussy), Appoline GEOLIER (Adj Tec; EPHE), Lorella GHONEIMI (Adj Tec; Paris Descartes), Sylvie LACHKAR (IE; Inserm), Isabelle MARTINS (IR; Gustave Roussy), Allan SAUVAT (IE; Paris Descartes), Valentina SICA (IR; Gustave Roussy), Gautier STOLL (IR, Paris Descartes), Erika VACHELLI (IR; Gustave Roussy).

Young Researchers: Elisa Elena BARACCO (PhD Student; Inserm), Lucilla BEZU (PhD Student; Univ Paris Sud), Francesca CASTOLDI (PhD Student; Inserm), Giulia CERRATO (PhD Student; Inserm), Guo CHEN (Post-Doc; Inserm), Fatima DE PALMA (PhD Student; Italie), Juliette HUMEAU (PhD Student; Univ Paris Sud), Julie LE NAOUR (PhD Student; Univ Paris Sud), Sarah LEVESQUE (PhD Student; Univ Paris Sud), Friedemann LOOS (Post-Doc; Paris Descartes), Florine OBRIST (PhD Student; Inserm), Juliette PAILLET (PhD Student; Inserm), Juncheng PAN (PhD Student; Univ Paris Sud), Maria PEREZ LANZON (PhD Student; Univ Paris Sud), Adriana PETRAZUOLO (PhD Student; Inserm), Jonathan POL (Post-Doc; Inserm), José Manuel SAN PEDRO (Post-Doc; Gustave Roussy), Ligia SILVA (Post-Doc; Gustave Roussy), Yan WANG (Post Doc; Sorbonne Univ), Alejandra WU CHUANG (PhD Student; Sorbonne Univ), Wei XIE (PhD; Univ Paris Sud), Liwei ZHAO (Post-Doc; Univ Paris Sud).

Administration: Lynda BENNACI.

Contact details: 33 1 44 27 76 67  email


 

Publications

  • Levine B, Kroemer G. Biological functions of autophagy genes: a disease perspective. Cell. In press
  • Villella VR, et al. A primordial pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease. EMBO J. In press
  • Kroemer G, López-Otín C, Madeo F, de Cabo R. Carbotoxicity-Noxious effects of  carbohydrates. Cell. 2018 Oct 18;175(3):605-614.
  • Obrist F, et al.  Metabolic vulnerability of cisplatin-resistant cancer cells. EMBO J. 2018 Jul 13;37(14). pii: e98597.
  • Gomes-da-Silva LC, et al. Photodynamic therapy with redaporfin targets the endoplasmic reticulum and Golgi apparatus. EMBO J. 2018 Jul 2;37(13). pii: e98354.
  • Sauvat A et al. Trans-fats inhibit autophagy induced by saturated fatty acids. eBiomedicine. 2018 Apr;30:261-272
  • Zitvogel L et al. The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies. Science. 2018 Mar 23;359(6382):1366-1370.
  • Pietrocola F, et aL Aspirin recapitulates features of caloric restriction. Cell Rep. 2018 Feb 27;22(9):2395-2407.
  • Xie Y, et al.  The tumor suppressor p53 limits ferroptosis by blocking DPP4 activity. Cell Rep. 2017 Aug 15;20(7):1692-1704.
  • Madeo, F et al., Spermidine in health and disease. Science 359 (2018)

 

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