AccueilAccueil>Alexia KANYAVUZ and Jordan DIMITROV published an article in Nature Reviews

Alexia KANYAVUZ and Jordan DIMITROV published an article in Nature Reviews

Alexia KANYAVUZ and Jordan DIMITROV published an article in Nature Reviews Immunology about unorthodox mechanisms for diversification of antibody specificity. Team: Immunopathology and Therapeutic Immuno-intervention

 

  Breaking the law: unconventional strategies

for antibody diversification

 

 

 Alexia Kanyavuz,  Annaelle Marey-Jarossay,  Sébastien Lacroix-Desmazes

and Jordan D. Dimitrov

 

 

Antibodies are essential components of adaptive immunity. A typical antibody repertoire comprises an enormous diversity of antigen-binding specificities, which are generated by the genetic processes of recombination and mutation. Accumulating evidence suggests that the immune system can exploit additional strategies to diversify the repertoire of antigen specificities. These unconventional mechanisms exclusively target the antigen- binding sites of immunoglobulins and include the insertion of large amino acid sequences, post-translational modifications, conformational heterogeneity and use of nonprotein cofactor molecules. Here, we describe the different unconventional routes for diversification of antibody specificities. Furthermore, we highlight how the immune system has a much greater level of adaptability and plasticity than previously anticipated, which goes far beyond that encoded in the genome or generated by the acquisition of somatic mutations

 

Link to the article:

https://www.nature.com/articles/s41577-019-0126-7

 

Les Outils